Clean-in-place ( CIP ) is a method of cleaning the interior surface of pipes, vessels, process equipment, filters, and related fixtures, without disassembly.
Until the 1950s, closed systems were disassembled and cleaned manually. The emergence of CIP is a boon to industries that require frequent internal cleanup of their processes. Industries that rely heavily on CIP are those who require high levels of hygiene, and include: milk, beverages, brewing, processed foods, pharmaceuticals, and cosmetics.
Benefits for industries that use CIP are faster cleaning, less labor and more repetitive, and less risk of exposure to chemicals for people. CIP begins as a manual practice involving the balance tank, centrifugal pump, and connection to the system being cleaned. Since the 1950s, CIP has evolved to include fully automated systems with programmable logic controls, dual balance tanks, sensors, valves, heat exchangers, data acquisitions and specially designed spray nozzle systems. Manually operated and simple CIP systems can still be used today.
Depending on the ground load and process geometry, the CIP design principle is one of the following:
- provides a highly volatile high flow rate solution for good cleaning (applicable for pipe circuit and some filled equipment).
- provide the solution as a low-energy spray to wet the surface completely (applies to a dirty laver where a static spray ball can be used).
- provide high energy stabbing spray (applies to very dirty or large diameter vessels where dynamic spray devices can be used).
Increased temperature and chemical detergents are often used to improve the effectiveness of cleaning.
Video Clean-in-place
Faktor yang mempengaruhi keefektifan agen pembersih
The temperature of the cleaning solution . Raising the temperature of the cleaning solution increases the efficiency of the sewerage. Molecules with high kinetic energy remove impurities faster than slow-moving molecules from cold solution.
Concentration of cleaning agent . A concentrated cleaning solution will clean the grimy surface much better than a dilute due to increased surface binding capacity.
Timing contact cleaning solution . The longer the detergent contact period, the higher the cleaning efficiency. After some time, the detergent finally dissolves the stain/hard soil from the dirty surface.
Pressure given by a cleaning solution (or turbulence) . Turbulence creates an abrasive force that removes stubborn soil from a dirty surface.
Maps Clean-in-place
Ground source
Originally developed to clear the enclosed system as described above, CIP has recently been applied to groundwater sources used for high-level use such as natural mineral water/springs, soft food and soft drink production (CSD).
Drill holes open to the atmosphere are susceptible to a number of chemical and microbiological problems, so sources for high end use are often sealed on the surface (main work). The air filter is built into the headwork to allow the drill hole to inhale and exhale as water levels rise and fall rapidly (usually because the pump is switched on and off) without attracting airborne particles or contaminants (spores, fungi, fungi, bacteria, etc.).
In addition, the CIP system can be built into the borehole head to allow injection of cleaning solvents (such as sodium hypochlorite or other cleansers) and subsequent recirculation of this chemical and groundwater mixture. This process of cleaning the interior and drill equipment without the necessary invasive treatment.
Bioreactors, fermentors, and mixing vessels
CIP is commonly used for cleaning bioreactors, fermenters, mixtures, and other equipment used in the manufacture of biotech, pharmaceutical manufacturing and food and beverage manufacturing. CIP is performed to remove or remove batch components of previous cell cultures. It is used to remove residues in the process, control the bioburden, and reduce the level of endotoxin in the equipment and processing system. Removal of residue is carried out during CIP with a combination of heat, chemical action, and turbulent flow.
The US Food and Drug Administration issued a CIP regulation in 1978 that applies to pharmaceutical manufacturing. The regulation states, "Equipment and equipment must be cleaned, maintained and sterilized at appropriate intervals to prevent malfunctions or contamination that would change the safety, identity, strength, quality or purity of drug products beyond the official requirements or other specified requirements."
Repeatable, reliable, and effective cleaning is of the utmost importance in manufacturing facilities. Cleaning procedures are validated to show that they are effective, reproducible, and under control. For clean processing equipment, equipment should be designed with smooth stainless steel surfaces and interconnected pipes with net connections. The chemical properties of the cleaning agent should really interact with the chemical and physical properties of the discarded residue.
A typical CIP cycle consists of many steps that often include (in descending order):
- Pre-rinse with WFI (water for injection) or PW (pure water) done to wet the inner surface of the tank and remove residue. It also provides a non-chemical pressure test of the CIP flow path.
- A single caustic solution flowing through the vessels to dry. Caustic is the main cleaning solution.
- The caustic solution returns through the blood vessels.
- Intermediate WFI or PW rinse
- Acid liquor Wash - used to remove mineral deposits and protein residues.
- Flushing with WFI or PW - rinse to cleanse the rest of the cleaning agent.
- Final air blow - used to remove the remaining dew after the CIP cycle.
Important parameters must be met and remain within specifications during the cycle. If the specification is not reached or maintained, cleaning will not be guaranteed and must be repeated. Critical parameters include temperature, flow rate/supply pressure, chemical concentration, chemical contact time, and final flushing conductivity (which indicates that all cleaning chemicals have been removed).
See also
- Guidelines for waste (US waste water)
- Waste restrictions
- Ice reply
- Waste Water
References
External links
- Clean Logic Programming
- Clean in place in pictures and diagrams
- Clean in Censorship
- On-site cleanup
Source of the article : Wikipedia
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